Knowledge workers are central actors for organizational performance and also widely in societies. Specifically, they are central sources, producers and orchestrators of knowledge, in which work creativity plays an important role. The goal of this paper is to shed light on determinants of knowledge worker creativity. We investigate resilience and self-efficacy as predictors of knowledge worker creativity by suggesting that effect of resilience is both direct and indirect, that is self-efficacy works as a partial mediator between knowledge worker resilience and creativity. We collected data from 419 knowledge workers in Finland to test the research model. The model was tested using partial least squares structural equation modelling (PLS-SEM). The findings supported our hypotheses. This study contributes to research on knowledge worker creativity and individual resilience in organizations.