This paper aims to investigate the impacts of food safety drivers on food safety climate of Italian agrifood companies. we empirically tested the relationship among food safety driver, leadership, internal communication, resources, and risk awareness. From March to May 2022, we gathered survey information from 168 Italian companies engaged in the agri-food industry. Results suggest that food safety drivers enhance each dimension of the food safety climate. This study is the first one that analyses the impact of food safety drivers on each food safety climate component, deepening the knowledge of the components of food safety climate in the Italian context. The main limitation of the present study is that we collected data from a single European Country and results cannot be generalized.