The main objective of this research article is s to briefly present the current state-of-the-art about the emerging innovation and entrepreneurial dynamics and the impact of the digital transformation in the Creative and Cultural Industries (CCIs) and to delineate potential future research directions. The paper combines a deductive and an inductive approach. The research outlines the needs to addressing in a more specific way the dimensions of innovation, the role played by digital transformation and the potential paths of entrepreneurship in CCIs. The value of the article mainly resides in its attempt to identifying and clarifying relevant themes and unanswered research questions about innovation and entrepreneurial dynamics in CCIs to be effectively declined and investigated according to an inter-disciplinary perspective.