The study aims to explore the digital transformation processes and related changes occurring in the knowledge-intensive sectors, focusing on university organizations. Thus, the study analyses whether and how universities are “exploiting” the value offered by digital technologies to embrace more innovative, sustainable, and inclusive organizational models, strategic paths of growth, and working practices/processes for successful advantage. To achieve the research aim, the study adopts a single-case study approach: the University of Naples “Parthenope”. After reviewing the relevant literature on digital technologies and their impact on teaching and research activities, an empirical investigation through a survey of a sample of students and academics of Parthenope is developed. The findings highlight variables and factors useful to strengthen the adoption of digital technologies at the University of Parthenope. The analysis should guide the universities to increase hinder competitiveness and innovation in education and research thanks to the use of digital technologies. This study offers theoretical analysis and practical guidelines useful to support universities in creating value and strategic growth by embracing digital technologies in teaching and research activities.