The economic and social impact of Covid-19 is not yet fully assessed. Although the recovery measures adopted by the Italian Government allowed for a compensatory action of the losses, the pandemic crisis heavily affected the Italian economy. If the economic effects of the pandemic will be significant almost everywhere, it can be assumed that in some areas they will be even heavier on the basis of the different economic conditions. Starting from this premise, this work intends to analyse the impact that the first emergency phase linked to the Covid-19 pandemic had on the Italian Regions. To this end, a forecasting model is proposed aimed at determining the impact of the pandemic on the Italian Regions and identifying which of these may have suffered most as a consequence of the pandemic crisis.