The increasingly complex and uncertain socio-economic scenario and the new challenges and opportunities of the digital revolution are forcing organizations to anticipate changes and boost more and more their innovation processes in order to maintain their competitive advantage. In such scenario, are emerging new spaces of action and interactions based on tangible and intangible elements that influence learning and knowledge processes and dynamics. These innovative learning spaces include a combination of elements enhancing the learning process, with a strong technological component. In such a context, how to manage and assess the effectiveness of learning spaces, especially based on advanced technologies, has become a key topic. Despite that, to date, how to assess the effectiveness of learning spaces remains under-investigated. This study proposes a conceptual framework that highlights the relevant variables and dimensions to assess in a learning space. For this purpose, the study adopts a systematic literature review approach. The theoretical findings suggest specific variables and dimensions to consider in assessing learning spaces, especially the ones supported by advanced digital technologies. Moreover, the paper provides managers with a conceptual framework supporting the decision-making process in managing and assessing LS.