The present study explores organizing knowledge co-creation for radical innovation within knowledge ecosystem. Building on research on knowledge creation, innovation, and organizing, the study at hand understands knowledge co-creation as central basis for organizing and source of interdependence. Study sheds light on temporary and emergent organizing of knowledge co-creation within knowledge ecosystem. The findings of the study reveal that process of knowledge co-creation is cyclic in which each cycle builds on previous one. In addition, knowledge co-creation considers multidimensional orientation between technology, business and regulation throughout the process. Hence, beyond formal project organization, organizing knowledge co-creation is temporary, dynamic, informal, and follows cyclic and generative process. Specifically, organizing comprises activities of shared problem identification, shared goal setting, making experiments (testing), open demonstrations, and seeking internal and feedback and knowledge synthesis. Such an organizing enables contextual, situational, and flexible involvement of critical knowledge for the development of innovation, building novel business, and changing regulation. The paper discusses the findings and implications more detailed.