This work reports preliminary outcomes from the project LINFA, whose aim is to develop a technological, information and organizational system to support the procurement process of medicines and medical devices within healthcare organizations. Such system integrates simulation and optimization algorithms and forecasting models along with advanced logistic practices and traceability technologies by exploiting the increasing availability of historical information about drugs and patients. Accordingly, the paper presents a real case study within an Italian Hospital where the project team has gone through-out the phases of process discovery, use-cases identification and analysis to devise an integrated tool for supporting logistic operation. Results provide a complete identification and formalization of the drug management process, primary process users and functional requirements of such tool for supporting pharmaceutical last-mile logistic including simulation utilities within a hospital or hospital network setting. Final expected benefits from the project include the minimization of stocks and the effective and efficient management of medicines, with a consequent reduction in healthcare expenditure.