Knowledge work (KW) has risen to a significant role in modern societies, leading to an increasing number of the knowledge workers. Digitalization changes the work life, challenging individuals representing different professions as well as organisations. KW and the traditional professions are changing in many ways, opening up new vistas. The purpose of this paper is to analyse and compare the enablers and restraints of KW in different professions, the medical practice, the clergy, the legal profession and the teachers. The paper seeks the KW enablers and restraints similar or different when digitalization changes inevitably the ways of working. The theoretical background for the paper is addressed by the concepts of professions and KW and certain professions. The empirical data was gathered with unstructured interviews using a narrative interview method. Questions were open so that the situations were similar to a discussion. The interviewer posed further questions to deeper the interviewee’s answers and to build the continuity of the interview upon them. Using the narrative interview method meant that the researcher tried not to influence or lead the interviewee to a significant extent and the differences and similarities could be seen as they are perceived by the respondents This methodology puts in evidence on similarity of working habits, socio-technical systems and work-flows of within and between professions. The originality of the study is laid on the unique comparison of different professional groups and the parallel analysis. The paper concludes by discussing the enablers and the restraints of KW in the era of digitalization in the chosen professions. The paper also builds profession related taxonomy of key findings and discusses those from the managerial perspective.