This study proposes a systematic literature review aimed at analyzing three key thematic areas: the conceptual and operational adoption of new operational paradigms related to the use of technology in the business environment (Industry 5.0), sustainability strategies in new business models (sustainability) and the concept of well-being in the workplace. The study examined 21 scientific articles selected from the Scopus and Web of Science databases, published in the period 2020-2024, considering the following keywords: industry 5.0, sustainability and well-being. The results highlight the crucial role of advanced technologies – such as artificial intelligence, collaborative robotics and the Internet of Things – in fostering safer, more efficient and well-being-oriented production environments for workers, with a positive impact on the overall sustainability of industrial systems. The ‘Industry 5.0’ phase is an evolution of the previous Industry 4.0, shifting the focus from pure automation to the enhancement of human capital, the ethical integration of technologies and the promotion of human-machine cooperation. It moves towards a society that is based on the use of technology for a more human, inclusive and resilient society, where technology is at the service of human well-being (Society 5.0). Findings reveal that technology is configured not as an end, but as a means for the improvement of collective well-being and quality of life and lastly for production systems that evolve by placing the person at the center: the goal is to reach the ethical integration of technologies through the human-machine collaboration.