The importance of gratitude in Multi Business Model Innovation (MBMI) has not been investigated much. However, it is vital to meet today’s increasing incidence of Volatile, Uncertainty, Complex and Ambiguous (VUCA) challenges by new concepts like gratitude as a psychological and MBMI leadership competence. This paper investigates the impact between gratitude and knowledge innovation in MBMI processes in Business Model Ecosystems (BMESs) influenced by VUCA Events. The impact of individual and business resilience caused by gratitude is studied in 3 MBMI cases as an important competence to endure challenging MBMI processes influenced heavily by VUCA Events. From the 3 cases a transfer of gratitude is outlined as a fundamental competence for creating valuable knowledge and resilience in individuals and in stakeholder networks. These observations correspond to the hypothesis that gratitude is a reciprocal competence and a psychological positive emotion which is a predictor for success in MBMI. Based on this hypothesis we propose gratitude as an important component in the MBMI mindset. The research is conducted in the view of knowledge creation, MBMI and gratitude theory – particularly the concept of wellbeing and positivity as a fundamental mental state for an increasing learning and knowledge creation – the vital “raw material” and competence in all MBMI processes. The research analyses qualitative results from interviews and observations with focus on gratitude as an individual and organisational core competence – and the impact of gratitude on creating strong MBMI processes and networks in a VUCA World.