The empirical study explains how the phenomenon of knowledge hub enables institutions establish collaborative linkages to boost their innovative performance. Knowledge hub helps cluster firms to develop an indispensable capability, anchored through exchange of knowledge locally, for accelerating growth and innovation in Asian region. Gaining sustenance from Dynamic Capability View (DCV), the study investigates perceived enterprises’ innovation performance as a result of inter-organizational relationships embedded with social ties and knowledge sharing among each other. This research proposes a moderated mediation effect on innovation performance, reflected through vigorous ICT enterprise innovations; supportive relationships pursuing emerging ICT initiatives and finally frequent transfer of knowledge with ultra-modern innovation concepts. It explains how inter-organizational relationships based on robust trust and commitment lead organizations to achieve higher levels of innovation performance, while sharing important knowledge among each other. It also examines the interaction effect of social capital on association between inter-organizational relationships on firms’ innovation performance with knowledge sharing as mediator. Cross-sectional data was collected from managerial level employees working in ICT enterprises in Pakistan. Model 4 of Process by Andrew Hayes was used to test the influence of inter-organizational relationships on enterprises’ innovation performance with mediation of knowledge sharing. Model 1 tested moderation for determining the interaction effect of social capital on relationship between inter-organizational relationships and knowledge sharing. Moderated mediation, exhibiting the conditional indirect effect was analyzed through model 8. The study findings stated that in knowledge hub, ICT businesses are collaborating to build strong social relationships while sharing practical experiences and support each other through abstract resources for achieving higher levels of innovative outcomes. Inter- organizational relationships have an affirmative impact on innovation performance, invariably, knowledge sharing mediates the correlation between both. The influence of inter-organizational relationships on innovation performance through knowledge sharing is significant for firms with strong social capital. Consistently, social capital considerably moderates the relationships, as such organizations co-ordinate and work jointly with other organizations for driving service and product improvements. The research steers focus towards developing relationships among ICT enterprises, building ties based on faith and exchange key information consistently to help and polish each other’s innovation capabilities.