This paper aims to uncover the determinants of University-Industry Cooperation (UIC) from an individual perspective, to identify which entrepreneurs’ characteristics affect the emergence of UIC and, more specifically, affect the selection of cooperation channels. To this purpose, we employed the Corporate Entrepreneurial Intention (CEI) model (Fini et al. 2012), which allowed to assess the effect of both individual and contextual factors in UIC dynamics, whether no previous attempts have jointly considered both types of variables in UIC literature. After applying structural equation modelling techniques to a sample of 130 entrepreneurs in the Region of Campania (South of Italy), our results show that corporate entrepreneurial behaviour is positively related to forms of UIC with an average and high level of complexity