Sustainability has become a crucial ethical imperative in determining the long-term prosperity of tourism destinations, given the urgent need to address global environmental challenges. This study focuses on the interconnection between cultural tourism and the Blue Economy, proposing an integrated view between the principles of the Blue Economy and cultural tourism. The aim is to explore the connections between the Blue Economy and underwater cultural heritage, and how the conservation of marine environments and the restoration of underwater cultural heritage can foster harmonious development, preserving ecological richness and promoting sustainable economic growth. The research adopts a qualitative methodological approach. Documentary and interpretive analysis is based on literature, websites, and reports relevant to the topic. The conclusions highlight the link between cultural heritage and the Blue Economy approach to promote responsible management of marine resources and enhancement of underwater heritage, presenting some actions and strategies implemented in Italy to enhance underwater heritage. Although this paper is a useful initial step to initiate and guide further research involving the presentation of case studies comparing different realities and approaches, to strengthen the interconnection between tourism and the Blue Economy, the use of this research methodology may be a limitation. Moreover, among the theoretical implications, it is proposed to broaden studies on these issues and suggest guidelines for future insights, considering the promising research area. In conclusion, this study explores how cultural tourism can drive economic development in harmony with the marine environment, offering an integrated vision between conservation, tourism, and the Blue Economy to foster the sustainable growth of tourism destinations.