In industrialised countries, and especially in Europe, the ageing of the population is steadily growing, leading to an increase of chronic diseases. It has been shown that telemedicine can be very useful for the care and treatment of chronic diseases. Our study examines chronic kidney disease (CKD), which is increasingly widespread among the world population (more than 7% of the world population is affected), and proposes a model of knowledge management system (KMS) supporting a telemedicine application for home hemodialysis. The present work aims to contribute to the knowledge management research by introducing a logical and operational model of KMS for teledialysis, which has been proposed and applied in the framework of an ongoing project involving 29 patients carried out at the Vito Fazzi hospital of the Lecce ASL (Italy). The study aims to address chronic kidney disease through new strategies, tools and care processes with a threefold objective: to improve patients’ health conditions and quality of life, to increase accesses to health services, and to reduce healthcare costs. The logical model describes the activities through a systemic view, and includes the technological components, process flows and organizational assets (including human capital constituted by all the actors involved in the management of CKD, i.e. nephrologists, qualified nurses, patients, care-givers). Through the model, a virtuous circle of acquisition, storage, processing and dissemination of data, information, knowledge, wisdom and experience is activated among all stakeholders involved in the management of CKD, improving and enhancing collaborative decision-making and doctor-patient relationships, which are crucial for the success of telemedicine services. As for the operational model, it aims to implement a KMS to support teledialysis services in the aim to observe the connection of systems, data and people required to enhance the medical decision-making processes, as well as the health conditions of patients and the quality of life of stakeholders, including the positive impact on the environmental sustainability of entire care processes.