Start-ups are becoming increasingly important in driving economic growth, job creation, and wealth generation. Their success depends not only on innovative products and services but also on the ability of attracting, retaining, and developing talented employees. The enthusiasm, involvement, and effort of founders and early employees greatly impact the success of start-ups. Unfortunately, the high degree of uncertainty, the intense work and multiple roles of employees may lead to several issues like burnout risk and difficulty balancing work and private life. Although existing research has produced several contributions on , the quality of working life for start-up employees and entrepreneurs, the knowledge generated in the field appears fragmented and the findings are sometimes ambiguous. The reason for this fragmentation can be traced back to the lack of reference frameworks that clarify the most used concepts,thus providing a shared language. Therefore, human resource wellbeing is a research theme that deserve to be further investigated. This study aims to provide a first attempt to consolidate the state-of-art of scholarly research in human resources wellbeing in innovative startups.. To this aim, we carried out a systematic literature review by analyzing a set of 41 papers in order to find what are the relevant topics in the investigated research domain. This activity was performed using MySLR software. In particular, we characterized the three relevant topics in the investigated research domain, namely job satisfaction, wages and career development opportunities; work-life balance and psychological wellbeing; women’s condition and gender related issues. Overall, the value of research is to provide a framework for analyzing the phenomenon of human resources wellbeing in innovative startups that can be used as a reference model for envisaging new research directions both entrepreneurship, human resources and innovation management fields of study.