Although telemedicine practices may be traced back to decades ago, their real potential has only been recognized during Covid-19 outbreak. As the pandemic has abated, the implementation of telemedicine has revealed many managerial considerations that are crucial for its optimal deployment. The technical and social connotation of telemedicine is central for both understanding and promoting its implementation. This dual nature has been shown to peculiarly affect the organization of work, in particular coordination among health professionals. This study investigates which coordination mechanisms are enacted within telemedicine services among health professionals and how these mechanisms unfold to achieve collective performance within these services. To do that, three case studies, concerning telemedicine services provided by public healthcare organizations in the Italian context, were analysed. Results shed novel light on coordination mechanisms enacted within telemedicine services and their integrated conditions, meant as the instruments through which coordination mechanisms unfold to achieve collective performance. Practical implications are discussed to support managers in interpreting how coordination mechanisms work within telemedicine services and consequently how to effectively design them.