An e-learning system, based on the Fee model (2009), consists of three components: technology, learning content and learning / e-learning design. In the literature on universities, there are not many contributions on the design of e-learning, understood as a process (Trentin, 2001). This article intends to understand, through an empirical analysis, how European universities implement e-learning design. In particular, the goal is to study the e-learning and design system, within selected European universities, to understand the phases of the project and to understand how much the university takes into account the territory. The study approach adopted to conduct the research was mixed: quantitative and qualitative. First of all, the quantitative survey was carried out on the websites of the top 100 European universities in the Quacquarelli Symonds ranking. Subsequently, the qualitative construction of some case studies and semi-structured interviews with managers of e-learning services of some European universities was carried out. The quantitative survey shows that the 100 best European universities, present in the Quacquarelli Symonds ranking, adopt e-learning methods, allowing to identify, among them, the universities involved in case studies. The qualitative construction of case studies and semi-structured interviews with managers of e-learning services of some of these European universities underlines a specific attention to the e-learning design of the courses, even if more focused on the professional figures working there and not entirely on the e-learning course project. The article aims to provide a detailed study on the design of e-learning in the educational context. The analysis of multiple case studies allows us to identify how the selected universities carry out the activity of educational design through the use of technology. The study has two main limitations. The first difficulty lies in the difficulty of having a complete view of the examined phenomenon. The second limit refers to the number of respondents and universities contacted. The future objective will be to intensify these activities by involving other actors (teaching staff, governance) and new universities.