The present research aims at defining the scope of an emerging phenomenon occurring in a peripheral suburb in the East area of the city of Naples (Italy), characterised by the settlement of a knowledge intensive Hub involving innovation, technology and knowledge transfer processes. The main subject of the study is the San Giovanni a Teduccio “Federico II” University Hub, a university campus and research centre named the San Giovanni Hub (“SGH”) or simply the “Hub”. Our work addresses the issue of innovation led by a knowledge-intensive context in a peripheral urban area. Such insight should enrich the specific focus on the competences of a university in terms of technology and knowledge transfer. The theoretical focus of the study is forged around the “Civic University” (Goddard, 2009) main characteristics, which draw from the transposition of the quadruple helix approach. The rationale underpinning the choice of the university engagement view (Holland, 2001) would help overcoming the vision of the University as “company-like” entity. The contribution to the theoretical framework resides in assessing the relevance of a knowledge intensive site embedded in a peripheral and less developed urban context in the light of the “Civic University” characterising features. Such insight should enrich the specific focus on the competences of a university in terms of technology and knowledge transfer. The outcomes of the analysis can be used as a valuable tool for both the University governance and managers of local urban institutions to promote or enhance knowledge transfer and entrepreneurial activities in the selected area.