This paper explores what knowledge governance mechanisms can be particularly relevant for innovation in the Brazilian context. A sample of 111 firms from Southern Brazil was surveyed. Hypotheses were tested using structural equation modelling (SEM). Our paper contributes to the knowledge governance and innovation literature by demonstrating that in the Brazilian context, infrastructural knowledge governance mechanisms are more important than people-focused ones. This study brings valuable information to managers of Brazilian firms to allow more efficient allocation of their resources and efforts for managing knowledge, and ultimately, innovation.