The purpose of this systematic literature review is to survey and evaluate the key works in the field of organizational unlearning and forgetting. Through analyzing and synthesizing common themes, we aim to highlight research gaps and new avenues for research in the field of organizational unlearning and forgetting. We intend to contribute to the debate and enhance the field by providing a better understanding of the topic. We conducted a systematic literature review to identify significant studies in the field of organizational unlearning and forgetting. After applying certain inclusion/exclusion criteria, we selected a final number of 63 relevant works which we thoroughly analyzed. Structuring the analysis and synthesis around various constructs, theories, typologies, and related themes allowed us to highlight several research gaps and propose avenues for further research. Although it is an under-researched field characterized by a blurry and fragmented understanding, the field of organizational unlearning and forgetting has received increased scholarly attention. We reveal fresh insights into this field of research and provide new avenues for future research. This paper contributes to a better understanding of the field and raises several additional questions to spark further debate. We highlight various processes and mechanisms of unlearning and forgetting and expose common themes in the analyzed literature. By reviewing relevant works in detail, we theoretically expand the overarching fields of knowledge management and organizational learning. Researchers from other disciplines might consider various aspects of this work for their own fields and, in turn, enhance interdisciplinary research efforts. This paper also aims at raising awareness of organizational unlearning and forgetting in companies. The outcomes of this work could benefit managers, consultants, employees, or other practitioners in terms of its strategic significance in order to enhance the competitive advantage and performance of their organizations. Particularly in knowledge-intensive environments, the effective and efficient management of knowledge is crucial. Successfully managing processes of knowledge loss can positively influence an organization’s performance. We outline some important factors that practitioners can consider when dealing with purposeful or involuntary knowledge loss.