Purpose The purpose of this paper is to better comprehend the interplay between MAS and innovation in research-intense networks. These networks are characterised by multifaceted knowledge sharing/integration/transfer processes that will be taken into account in order to understand how an effective MAS can positively affect innovation, and in turn how innovation shapes MAS. Design/methodology/approach The research employs the single case study of a research-intense network located in Campania, namely Campania Bioscience, and investigate these issues through the lens of the Middle Range Thinking (MRT) approach developed by Broadbent and Laughlin (1993, 1997, 2003, 2005, 2013) advancing the Habermas Theory about Society, since this is particularly suitable to examine the issues relating to an on-going strategic change in management accounting practices fostered by changing environmental conditions. Originality/value The novelty of this paper relies on the possibility to explore the peculiarities of an effective MAS supporting the innovation processes within a complex setting such as the researched network, that involves multifaceted knowledge sharing/integration/transfer. Moreover, it offers a newer perspective of analysis to interpret the role of MAS in innovative networks, thus contributing to the growing debate on the antecedents and facilitators of knowledge sharing and knowledge integration. Practical implications Our findings will be will to all the organizations involved complex processes of co-production of knowledge and innovation. Indeed the study broadens current knowledge on the factors that may contribute to bringing about an effective and positive interaction between MAS and innovation, relevant for both professionals and practitioners, opening the well-known “black box” of the creation/sharing/transfer/integration of tacit knowledge.