Purpose – After an introductory approach on the definitions and main characteristics of the knowledge economy the paper focuses on the three following purposes: 1) Discovering from the existing relevant literature on competitiveness, innovation and intellectual capital at the macro level which are the principles and theories that guide nations’ wealth creation in the knowledge economy context. This part tries to answer two fundamental questions: Who creates wealth? How wealth is created? 2) Finding out the suitable methodology or framework in order to enable an in-depth diagnosis of a nation’s actual knowledge driven competitiveness foundations, with the aim to aiding in the definition of the possible vision, objectives and lines of action to embrace in order to enable innovation and sustainable economic growth. 3) Applying the suitable methodology or framework for an in-depth diagnosis of the Spain crises and using the insights given by the in-depth diagnosis for having some light on the future economic development possibilities and on lines of action to be taken in order to foster innovation and sustainable economic growth. Design/Methodology/Approach – This practical research falls among the design science research approach that tries to find out methodologies for solving practical problems. Having in mind the practical objectives of purpose 3, the methodology approach for purpose 2 will be the following: According with principles and theories of wealth creation there is a close relationship between wealth creation and competitiveness and consequently trying to find out methodologies and frameworks for an in-depth practical diagnosis of a nation’s knowledge driven competitiveness foundations, leads us to the World Competitiveness Report from World Economic Forum (WEF) and World Competitiveness Yearbook from International Institute for Management Development (IMD), the two most relevant considering their up to date data bases, historical performances and scientific approach. Intellectual Capital community methodologies at the macro level are also considered as alternative approaches to the competitiveness frameworks. Finally we finish the review and valuation of competitiveness and IC macro dimension frameworks considering NICBS (Nations’ Intellectual Capital Benchmarking System) and enhanced NICBS methodologies as the more suitable for the above in-depth mentioned diagnosis. In essence the approach followed in purpose 3 has been a review of scientific literature on competitiveness and IC macro dimension with the exclusive aim of finding out the practical framework that could make it possible an in depth analysis of a nation knowledge based competitiveness foundations. Originality/Value – The paper is fully original because the in-depth economic reflection on the crise of Spain is performed using methodologies and frameworks that consider knowledge and other intangibles as the main foundations of competitiveness, innovation and sustainable economic growth. Theoretical/Practice implications – The reflections arising from the paper have mainly practical implications and will guide in the decision making process not only savers and investors but also government and institutional authorities.