The role played by cultural distance in affecting IJVs’ knowledge management is not well understood as there is still a lack of consensus among the main literature. First, the influence of cultural differences on IJV’s knowledge management has generated contradictory results. Second, how and why national and organizational culture affect IJV’s knowledge management remain vague. The main aim of this study is to fill this gap in the literature, by investigating how the dynamics of national and organizational culture influence knowledge management processes in IJVs operating in a cross-cultural business environment. We adopted a cross-case analysis, based on an embedded case study (the IJVs of the Generali Group in China with China National Petroleum Corporation and in India with Future Group). We used multiple sources of evidence: interviews, field observations, and internal document analysis. We performed cases analysis following a four-step method: within-case analysis, data reduction, cross-case analysis, and conclusion drawing/verification. In order to provide a more systematic visualization and comparison of all the cases at once, a meta-matrix by categories and research questions was also displayed. There is still a lack of consensus about the exact nature of the relationship between cultural differences and IJVs’ knowledge management. What kind of impacts does cultural distance have on IJVs’ knowledge management? Which is the role of national and organizational culture in affecting IJVs? Do they have a direct or mediated influence on IJVs’ knowledge management? There is still a lot of debate about these questions and a deeper knowledge of how national and organizational culture are interrelated and affect IJVs’ knowledge management processes is therefore needed. The paper provides managers with guidelines on how to cope with cultural distance issues when dealing with IJVs’ partnership processes (negotiating terms, managing the IJV, transferring and managing knowledge to the IJV).