The emergence of Digital Innovation Ecosystems (DIEs) is reshaping how innovation is generated, diffused, and scaled across sectors, especially within highly regulated domains such as pharmaceutical logistics. These ecosystems bring together startups, corporations, research institutions, and intermediaries to co-create digital solutions. However, such collaborations are inherently asymmetric—startups and corporates differ vastly in resources, legitimacy, and influence—posing challenges related to power imbalances, cultural misalignments, and governance.
This paper investigates how asymmetric collaborations are orchestrated within DIEs, drawing on a single in-depth case study: Logi-farma, a digital platform project aiming to optimize pharmaceutical distribution through AI, automation, blockchain, and data analytics. The case involves a large ICT corporation, an innovative SME, a logistics specialist, and a university research center. Guided by a conceptual framework derived from a prior systematic literature review on asymmetric collaborations, this study explores how stakeholders with diverging capabilities and motivations coordinate innovation efforts and mitigate power asymmetries.
Using semi-structured interviews, document analysis, and comparative assessments of digital innovation models, we investigate the governance mechanisms, collaboration dynamics, and innovation outcomes within the project. Findings are structured through a 6W-based framework—exploring who the actors are, how they collaborate and integrate technology, why they engage, and where/when the processes unfold. The analysis reveals that while startups benefit from legitimacy and scale, corporates leverage agility and niche expertise. However, unresolved asymmetries around data ownership, IP, and decision-making risk undermining trust and long-term viability.
This paper contributes to both theory and practice. Theoretically, it advances open innovation and ecosystem literature by integrating asymmetry as a structural component and proposing a novel conceptual lens for analyzing goal-oriented, multi-actor innovation networks. Practically, it offers guidance for ecosystem orchestrators, policymakers, and innovation managers on how to design inclusive governance structures that support fair value co-creation. The case study illustrates how digital health innovation can be scaled through collaborative orchestration, provided that power differentials are addressed and trust is actively managed. Ultimately, this work underscores the potential of orchestrated asymmetric collaborations to drive digital transformation and sustainability in complex, high-stakes sectors.