This study aims to analyze the entrepreneur’s use of social media especially in terms of knowledge exchange and acquisition. Intellectual Capital of organizations is essential to investigate entrepreneurs’ behaviour in their knowledge processes. In this study the Intellectual Capital framework is used to study the role of social media utilization in the knowledge exchange processes of start-ups. The methodological procedures of the research were predominantly qualitative. A questionnaire was distributed to a sample of entrepreneurs. The questionnaire focused on social media and how these are changing the way to create and exchange knowledge. This paper reports a descriptive analysis of the obtained results. This study puts in evidence the role of Social Media in the knowledge creation and exchange processes of start-ups. As a consequence, this paper examines social media utilization investigating, in particular, how intellectual capital drives entrepreneurs knowledge acquisition. Our descriptive analysis on the data collected allows a deeper understanding of social media usage on entrepreneurs’ knowledge processes. These results can contribute to the development of tools, such us guidelines, methods and indicators, aimed to better manage intangible in young high technology firms. Such tools are be useful both for entrepreneurs and managers and for consultants.