This paper aims to fill in the gap of investigating the relationship of strategy development and knowledge strategy and the integrating role of key strategy management tools and techniques between business strategy and knowledge strategy influenced by the culture the organization operates in. The paper first introduces different approaches of strategy development and the general process of developing an organizational strategy. It continues with the most used strategic management tools and techniques based on the results of the Bain & Company 15th Management Tools & Trends’ empirical survey. The most used management tools and techniques are also presented in details. The survey has been conducted in different countries and the results are summarized in different cultural clusters. Thus, the paper introduces the characteristics of these cultural clusters highlighting the similarities and differences among them. The comparative analysis in this case is rooted in the dimensions of Hofstede’s model of national culture. Furthermore, the paper discusses why the preferences in the usage of strategic management tools and techniques differ in these cultural clusters. This is followed by focusing on different knowledge strategies identified by De Toni et al. (2011). Besides the analysis of the differences of preferred knowledge strategies in different cultural clusters, the paper also aims to reveal the knowledge strategy being more effective in given cultural clusters. The paper helps practitioners and academics to understand the role of culture in the strategy development process and knowledge strategies implementation. Several papers have been dealing with management tools and techniques from a very technical perspective introducing empirical research results on how to use them in practice. Other papers analyze the values of the dimensions of national culture according to Hofstede’s database. However there is a lack of combination of these two fields and this paper highlights the importance of using management tools and techniques adequate to the cultural characteristics of the organizational environment. For strategic decision makers it is of high importance to take cultural differences also into consideration during the organizational and knowledge strategy development process. The paper helps leaders of multinational and international companies to understand why certain management tools and techniques are preferred in different cultures. Furthermore, an integrated view is provided for leaders on organizational and knowledge strategy development, on effectively applicable management tools and methods applied for the development process, and the adjustment of these strategies to each other.