Aim of this paper is to provide a knowledge-based perspective about the Entrepreneurship Education (EE). Despite EE has recently emerged as a relevant enhancing factor to support innovation and entrepreneurial dynamics, little attention has been paid to the identification and the operationalization of the knowledge assets dimensions grounding effective EE programs. To fill this gap, this paper first elaborates a dedicated conceptual framework and then provides a set of case examples to show the theoretical framework’s application to current real EE programming. The paper combines a deductive and an inductive approach. Specifically, first, a conceptual framework is elaborated to identifying the potential knowledge-based dimensions for EE. Then, it is tested and applied in three real EE programs recently developed in Italy and in Finland. The study proposes one of the first conceptual framework supporting the identification and the interpretation of the potential knowledge assets dimensions grounding EE programs and a set of empirical evidences collected through multiple case examples. This paper contributes to developing the literature on EE according to a knowledge- based perspective.