The Health Technology Information (HTI) is an important driver for change for the health sector. The evolution of HIT impacts directly on the health system. Health Information Technology is defined as “the application of information processing involving both computer hardware and software that deals with the storage, retrieval, sharing, and use of health care information, data, and knowledge for communication and decision making” (Thompson and Brailer, 2004; Payton et.al, 2011). The main electronic software of HIT is health records (EHR longitudinal), health medical records (EMR) and electronic prescribing. It can be expected that the utilization of HIT could lead to care coordination and improved outcomes. In this article the purpose is to make in evidence the creation processes di new knowledge thought the HIT tools. Also, we make a review of the scientific studies on the implementation of the different health information technologies. Consequently, this study may fill the gaps that previous studies may have encountered due to the timing of the studies prior to EHR – EMR implementation. The involved sample is the Scientific Institutes (IRCCS) located in Italy and specifically in the Sicily Region.