This paper proposes a new theoretical approach, borrowed from resilience studies, in order to better understand the role and success factors of science & technology parks in today’s complex scenario. This paper presents the in-depth qualitative analysis of an important Italian science & technology park. In this exemplary case, the park managers and decision-makers adopt or advocate some cultural principles and organizational practices that are highly compatible with the Adaptive Management approach. The case allows the authors to highlight how this approach influences the success of the science & technology park under analysis. To the best of the authors’ knowledge, this is the first time that the adaptive management approach is proposed to investigate the organizational and management issues of science & technology parks. The levels of success of science & technology parks are far from being uniform, and their success factors have been only partially understood so far. Therefore, the theoretical integration proposed by this paper may help support the resilience and sustainability of some of the most important innovation clusters in the EU.