This study highlights the huge diversity of the possible theoretical views of the role of knowledge in tourism destination networks. For this purpose, this paper provides a synoptic comparison of the relevant explanations and predictions that can be deduced from six important theoretical views, including both well-established, mainstream organizational theories and emerging inter-disciplinary approaches. The six theoretical clusters considered for this study are investigated through a comparative analysis of the literature. The results are synthesized in a prediction matrix. The results of this study show that the six theories differ significantly as for the expected benefits and success factors of knowledge management and organizational learning in tourism destination networks. Overall, the six-theory matrix offers a rich and complex framework with a strong explanatory potential, which calls for the setting-up of clear criteria of meta-theoretical brokering and integration. In the final part of the paper, the authors discuss the managerial implications of the six-theory prediction matrix. In particular, the authors highlight the possible usefulness of the pluralism of possible management criteria implied by the prediction matrix.