Over the years, industries have increasingly implemented the transdisciplinary approach to research complex topics such as planetary and human health. Indeed, transdisciplinarity removes boundaries between disciplines to create new frameworks and approaches for solving real-world problems. Such an approach is particularly crucial in healthcare due to the systemic understanding required to solve its emerging challenges. At the same time, innovation literature affirms that the development of current technologies, which are also emerging in healthcare, is by nature transdisciplinary. Studies on digital health solutions reveal their central role in providing treatments, especially non-pharmaceutical ones. These are often developed by combining disciplines such as medicine, psychology, and art to treat diseases related to the emotional and behavioural sphere of the human being, while reducing healthcare costs. The emerging digital health solutions named “Digital Therapeutics” (DTx) are central in providing these care pathways. DTx are evidence-based, software-driven medical interventions providing cognitive-behavioural and emotional therapies. Despite the practical and theoretical relevance to transdisciplinary research, innovation and knowledge management literature still lack a comprehensive understanding of how DTx enhance a transdisciplinary approach to non-pharmaceutical treatments. The authors investigated two DTx providing music therapy by implementing a qualitative multiple case-study to explore the potential of such technology as a driver of new knowledge management strategies in healthcare. Three mechanisms emerged from a thematic analysis. The findings contribute to the current literature on knowledge and innovation and the emerging stream of research on DTx, which are presented as catalysts for integrating diverse forms of knowledge within therapeutic research. Moreover, this research supports practitioners in understanding how to approach digital health solutions when providing non-pharmaceutical treatments, increasing the effectiveness and accessibility of care, and reducing unnecessary costs.
