This study aims to conduct a comprehensive investigation into the managerial and organizational literature concerning the intricate relationship among gazelles, unicorns, high-growth start-ups (HGFs), and innovation, specifically within the fields of Business, Management, and Accounting (BMA) as well as Decision Sciences. Employing a systematic literature review (SLR) methodology, this research utilizes Elsevier’s Scopus database to access relevant publications. Through this approach, the analysis facilitates a rigorous and critical evaluation of high-growth entrepreneurship, with a specific focus on developing a conceptual framework that elucidates the key determinants driving innovation within these high-growth entrepreneurial entities. This systematic review not only elucidates the implications and opportunities arising from established research trajectories but also identifies overlooked areas warranting further investigation. By synthesizing the findings, the study offers valuable managerial insights and recommendations, thereby contributing to a deeper understanding of the dynamics between high-growth entrepreneurship and innovation in the current organizational environment.