Museums contribute to urban regeneration processes and wellbeing of communities. Museums and communities help improve urban spaces and quality of life. Culture helps to support urban innovation, opening up to urban regeneration as a source of well-being for communities. Social innovation, as well as a dynamic vision for urban change management and sustainable development, might be enhancing factors. Museums contribute to urban redevelopment strategies and act as social agents of change and spaces of cultural innovation and experimentation to revitalize urban spaces, fostering solidarity, integration, and collaboration. Museums select a pathway for building community wellbeing, by developing social innovation, and driving urban regeneration processes that benefit urban communities and environments.