This paper explores the relationship between Entrepreneurial capital (EC), Leadership and Innovation performance (IP) in small and medium enterprises (SMEs) of the high-tech sector in Argentina. For this study survey data were collected in small and medium sized high-tech firms in Argentina using scales previously validated internationally. The data were collected from November 2020 to March 2021 (excluding the analysis of COVID-19 influence, and referring to year 2019) by mailing to the companies’ CEOs. The final sample comprises 200 companies from the technology-based sector located in Argentina. Hypothesis were tested using structural equation modelling in ADANCO. There is scarce research carried on how Entrepreneurial capital and leadership influence innovation performance as a key factor for survival in crisis times, for small and medium sized high-tech firms. This study aims to fill the literature gap by exploring the relationship between the Entrepreneurial capital (EC), the CEO leadership and the Innovation performance of technology-based small and medium enterprises (SMEs) on an emerging economy. This study brings useful and valuable information to managers of small and medium sized enterprises of the high-tech sector, by identifying the importance of entrepreneurial capital (EC) and leadership impact on innovation performance.