The term eHealth includes multiple components, like the Mobile Health (mHealth), the Health Information Systems (HIS), the Telemedicine and the Distance Learning (eLearning). With the aim to explore some of the main eHealth governance issues at stake and the challenges faced at national and global levels, for the purposes of this paper, authors propose an integrative review on crosscutting eHealth governance issues and call for the development and adoption of appropriate policies and an international well-coordinated governance. Although eHealth projects and initiatives are growing, worldwide scenario is still one of piecemeal implementation often lacking a system approach at national level and coordinated governance internationally. The trend toward Health 4.0, extending eHealth to the Internet of Things in health, will require a deeper analysis on what is really at stake in terms of human rights, universal access to health services and further commodification of health needs, in that sense due to the global nature of the Internet, national policies will necessarily need to be part of a global governance framework based on solid international cooperation.