Purpose –The focus of this paper is to highlight process and outcomes of interdisciplinary communication. In particular, the starting point is an established dialogue in the field of art and science. The background to this dialogue is constructed so as a response to the request by a community of scientists to communicate to the general public their research in human cell division and mitosis. Design/methodology/approach – The proposed approach is an arts-based practical approach, reflecting on a series of actual collaborations created between pairs of renowned artists and scientists, analysing the process and the outcome using as reference point the established field of dissemination of knowledge through comparisons and differences between professional activities and cultures. Originality/value –This methodology puts in evidence the actual process in action of generating an exhibition and making a documentary film with the artists and the scientists, against a firm background of historical information and contemporary scientific developments. Practical implications – The project that serves as the basis of this paper has a practical realisation of three exhibitions and one documentary film, with a series of meetings and exchanges that have taken place throughout a period of five years between artists and scientists.