In Italy, the healthcare sector is the one that absorbs the largest economic resources, immediately after Social Security, and, hence, it has been coping with an enduring reforming process. The latest health reform, namely DM 70/2015, suggested the adoption of the Hub & Spoke model for the redesign of regional hospital networks. The aim of this intervention was to have a capillary presence of less specialized disciplines, concentrated at the Spokes, in order to improve users’ accessibility conditions. In this paper, we deal with a particular case study concerning the STEMI (ST-Elevation Myocardial Infarction) network of the province of Naples, in Southern Italy. In particular, we perform a spatial analysis in order to assess the impact on users’ accessibility determined by the occurred reconfiguration. Moreover, we also propose a mathematical programming model aiming at producing alternative reorganization scenarios to improve spatial accessibility. Our results confirm that users effectively benefit from the reorganization process but also that further, and significant improvements, are possible. In particular, our computational experiments reveal that a strategic intervention oriented at redistributing capacities, i.e. the supply of hospital beds, among the existing facilities could lead to averagely better and even more equitable accessibility conditions.