The paper presents the results of the study aimed to identify the differentiation of knowledge management (KM) methods and tools depending on the certain knowledge domain. Identification and systematization of KM methods and tools was initially based on the literature review. Specifics of KM for several domains were studied using surveys, case study and interviews. New methods for the selected domains were developed with the help of design science research methodology. Then the results were discussed and reviewed through the interviews with KM experts during several international conferences. This research puts in evidence on the issue of KM methods suitable for the particular knowledge domain and type. The KM tools and methods are classified into universal, multidomain (for example, communities of practice, libraries or knowledge bases, banks of ideas), and domain-specific. Systematization of universal KM tools and methods is based on the stages of knowledge transformation process (knowledge life cycle). Domain-specific KM tools and methods are structured according to the areas of knowledge identified on the generalized knowledge map. The research focuses on a number of domains (customer knowledge, knowledge of the product / service, knowledge in operational and strategic management, knowledge for the production and design of products / services), and industries (oil and gas, software development, in the field of enterprise management). The study of KM tools and methods in different domains allowed classifying tools and methods into following groups: 1) tools and methods that were originally designed to solve problems in a certain domain; 2) tools and methods that were originally designed to work with information [+ staff practices + management practices] in a certain domain and consequently expanded to other KM domains; 3) tools and methods that actually solve KM tasks in a certain domain, but are not called KM tools. Described in the study interrelations between knowledge domains, KM methods and tools may help knowledge managers to select а proper method/tool for their business tasks. Tools and methods that actually solve KM tasks in a certain domain, but are not called KM tools; enrich the set of KM methods and tools for further research.