Universities play a crucial role in fostering entrepreneurship and innovation, extending beyond their traditional missions of research and education. This paper investigates the evolving model of entrepreneurial University, focusing on the evolution toward a network model based on the creation of entrepreneurial and innovation ecosystems in the university context. Starting from the analysis of FabLabs movement, the paper explores the motivations and development process of DFGN (Design Factory Global Network). Furthermore, through the examination of the Design Factory of the University of Bologna, Oper.space, the paper illustrates how these networks integrate maker philosophy and design thinking to support entrepreneurship education and provide infrastructure necessary for innovation. The analysis highlights the impact of DFGNs on University Entrepreneurship. While this study provides an initial exploration, further research is recommended to delve deeper into the relationship between DFGNs and FabLabs within universities and to examine the reasons behind the establishment of DFGNs at various institutions.