Italian Inner Areas are fragile territories, often offering only essential services and thus characterised by depopulation and degradation. The National Strategy for Inner Areas (SNAI) is a recent innovative Italian policy to counteract marginalisation and demographic decline by creating new employment circuits and chances of local development through territorial cohesion. In recent years, some public policies are working towards this final goal: for instance, the Law 158 of 2017 (“Measures for the support and enhancement of small municipalities”) and its National Plan or the public call “Projects of cultural and social regeneration of small historic villages” (within the National Recovery and Resilience Plan), which promote projects for regeneration, enhancement and management of the cultural heritage in small Italian villages. Currently, also several research projects are carried on to study how to reactivate these fragile contexts: i.e., “Branding4Resilience (B4R)”, which the paper refers to, funded in 2019 by the Italian Ministry of Education, University and Research. B4R involves four academic partners with the aim of investigating the potential of branding in four Italian inner areas, by proposing the implementation of minimal tourist infrastructures as an engine for the development of resilient territories and local communities. By assuming a knowledge management perspective, the aim of the paper is to propose a methodological approach, structured in five processes and a series of phases, aimed to explore fragile territories and to support the identification of some territorial resilience strategies. This approach was applied to the case of Alta Valsesia, located in the northern Piedmont (Italy), which is one of the inner areas studied within the “B4R Branding4Resilience” research project. By using different dimensions and sub-dimensions of analysis, a series of indicators and indexes were jointly analysed not only to support a first exploration of the territory potentials, but also to highlight territorial vulnerability and vibrancy aspects. Some first results, obtained from spatial and attribute queries in relation to the objective of developing new cultural-touristic infrastructures, supported the identification of the most fragile areas of Alta Valsesia, which deserve a particular attention and priority in funding enhancement strategies and actions. On the basis of these results, a co-design workshop with local stakeholders and B4R research groups was organized to foster enhancement strategies, design actions/interventions and identify possible funding sources to guarantee their economic- financial sustainability.