Innovation ecosystems’ main purpose is to foster innovation. While referring to these ecosystems, the local dimension presents several advantages: indeed, the closeness could improve the interactions between the actors. However, the openness related to the global innovation ecosystems enable efficiently the collaborations across the organizations. The aim of this research, indeed, is to deepen the trade-off between the local approach versus the internationalization strategy implemented with the multinational. In line with our purpose, we developed firstly a case study approach to directly observe the phenomenon and secondly, we developed a system dynamics simulation, which allows us to compare the innovation value generated by both the ecosystems.