This paper provides a structured literature review (SLR) on knowledge management (KM), digital transformation, and Industry 4.0. The study aims to define all the interactions, ties, and interdependencies between the three research streams. As an essential role in a progressive discipline, our research summarises the state of the art of past and current literature using the Massaro’s et al. (2016) methodological paper. The researchers adopted the Scopus database and their analysis as tools for the Bibliometrix R package to collect bibliometric data. The analysis reveals 561 peer-reviewed of English articles. The study shows some research clusters that coincide with the following survey areas: KM and ICT, KM and frontier technologies, KM and decision-making, KM and Industry 4.0, and KM and innovation. Finally, this article’s originality emphasises the crucial role of digital transformation for KM development in Industry 4.0, addressing future research perspectives.