This paper aims to review and critique the Knowledge Management (KM) literature within Entrepreneurial universities, providing an overview of the results of a content analysis aimed to setup the emerging trends and suggest directions for future studies. The content analysis has been conceived into a larger and systematic literature review conducted on 1106 articles indexed at Scopus and initially submitted to a bibliometric analysis. Finally, 150 papers published in a variety of academic journals specializing in the field of Entrepreneurship, KM and Higher Education have been analyzed through a content and a bibliometric analysis to minimize mistakes in interpreting findings of collected studies. To undertake such analysis, we have used VOSviewer, a tool for constructing and visualizing bibliometric networks and clusters. KM within Entrepreneurial University is a research area of growing importance. Findings show that literature on KM models and tools in the Entrepreneurial University is fragmented and dominated by unrelated research. The content analysis here presented depicts the trends of a heterogeneous literature, but focused on some research streams such as: 1) Knowledge creation in Entrepreneurship Education; 2) Knowledge transfer in University-Industry collaboration; 3) Entrepreneurial University to support Knowledge based regional development; 4) KM processes for University’s spin-offs. Implications for theory and practices are depicted.